Genetic construction and properties of a diphtheria toxin-related substance P fusion protein: in vitro destruction of cells bearing substance P receptors.
We have genetically replaced the native receptor binding domain of diphtheria toxin with an extended form of substance P (SP): SP-glycine (SP-Gly). The resulting fusion protein, DAB389SP-Gly, is composed of the catalytic and transmembrane domains of diphtheria toxin genetically coupled to SP-Gly. Be...
Збережено в:
| Опубліковано в:: | Proc Natl Acad Sci U S A |
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| Автори: | , , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
National Academy of Sciences
1996
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692995/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.7341 |
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