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Genetic construction and properties of a diphtheria toxin-related substance P fusion protein: in vitro destruction of cells bearing substance P receptors.

We have genetically replaced the native receptor binding domain of diphtheria toxin with an extended form of substance P (SP): SP-glycine (SP-Gly). The resulting fusion protein, DAB389SP-Gly, is composed of the catalytic and transmembrane domains of diphtheria toxin genetically coupled to SP-Gly. Be...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Fisher, C E, Sutherland, J A, Krause, J E, Murphy, J R, Leeman, S E, vanderSpek, J C
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38986/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692995/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.7341
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