A Novel Prolyl Hydroxylase Inhibitor Protects Against Cell Death After Hypoxia

Hypoxia-inducible factor 1 (HIF-1) is regulated by the oxygen-dependent hydroxylation of proline residues by prolyl hydroxylases (PHDs). We recently developed a novel PHD inhibitor, TM6008, that suppresses the activity of PHDs, inducing continuous HIF-1α activation. In this study, we investigated ho...

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Autores principales: Kontani, Satoru, Nagata, Eiichiro, Uesugi, Tsuyoshi, Moriya, Yusuke, Fujii, Natsuko, Miyata, Toshio, Takizawa, Shunya
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2013
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898357/
https://ncbi.nlm.nih.gov/pubmed/24132642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-013-1175-0
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