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A Genetically Encoded FRET Sensor for Hypoxia and Prolyl Hydroxylases
Oxygen is vital for all aerobic life forms. Oxygen-dependent hydroxylation of hypoxia-inducible factor (HIF)-1α by prolyl hydroxylase domain enzymes (PHDs) is an important step for controlling the expression of oxygen-regulated genes in metazoan species, thereby constituting a molecular mechanism fo...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026574/ https://ncbi.nlm.nih.gov/pubmed/27385075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00330 |
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