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A Genetically Encoded FRET Sensor for Hypoxia and Prolyl Hydroxylases

Oxygen is vital for all aerobic life forms. Oxygen-dependent hydroxylation of hypoxia-inducible factor (HIF)-1α by prolyl hydroxylase domain enzymes (PHDs) is an important step for controlling the expression of oxygen-regulated genes in metazoan species, thereby constituting a molecular mechanism fo...

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Bibliografski detalji
Izdano u:ACS Chem Biol
Glavni autori: Youssef, Suzan, Ren, Wei, Ai, Hui-wang
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026574/
https://ncbi.nlm.nih.gov/pubmed/27385075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00330
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