Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

Myelotoxicity during thiopurine therapy is enhanced in patients, who because of single nucleotide polymorphisms have decreased activity of the enzyme thiopurine methyltransferase (TPMT) and thus more thiopurine converted into 6-thioguanine nucleotides. Of 601 children with acute lymphoblastic leukem...

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Autores principales: Schmiegelow, K, Forestier, E, Kristinsson, J, Söderhäll, S, Vettenranta, K, Weinshilboum, R, Wesenberg, F
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898327/
https://ncbi.nlm.nih.gov/pubmed/18987654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2008.316
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