Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation

Imiquimod (IMQ), a nucleoside analogue of the imidazoquinoline family, is used in the topical treatment of basal cell carcinoma (BCC) and other skin diseases. It is reported to be a TLR7 and TLR8 agonist and, as such, initiates a Th1 immune response by activating sentinel cells in the vicinity of th...

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Autores principales: Wolff, F, Loipetzberger, A, Gruber, W, Esterbauer, H, Aberger, F, Frischauf, A M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898320/
https://ncbi.nlm.nih.gov/pubmed/23995793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.343
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