Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B

Anti-apoptotic Bcl-2 family members can contribute to tumorigenesis and may convey resistance to anti-cancer regimens. Therefore, they are important targets for novel therapeutics, particularly Bcl-2 homology (BH)3 mimetics. Bcl-B (BCL-2-like protein-10) is a relatively understudied member of the Bc...

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Main Authors: van de Kooij, B, Rooswinkel, R W, Kok, F, Herrebout, M, de Vries, E, Paauwe, M, Janssen, G M C, van Veelen, P A, Borst, J
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898306/
https://ncbi.nlm.nih.gov/pubmed/23563182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.99
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