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The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.

Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent mechanisms for the regulation of protein stability and cellular function. We previously reported BAG3 overexpression protected ubiquitinated clients, such as AKT, from proteasomal degradation and conf...

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Bibliographische Detailangaben
Hauptverfasser: Victoria M Virador, Ben Davidson, Josephine Czechowicz, Alisha Mai, Jareer Kassis, Elise C Kohn
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2009-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC2662420?pdf=render
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