Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

Sirt3 is a mitochondrial NAD(+)-dependent deacetylase that governs mitochondrial metabolism and reactive oxygen species homeostasis. Sirt3 deficiency has been reported to accelerate the development of the metabolic syndrome. However, the role of Sirt3 in atherosclerosis remains enigmatic. We aimed t...

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Détails bibliographiques
Auteurs principaux: Winnik, Stephan, Gaul, Daniel S., Preitner, Frédéric, Lohmann, Christine, Weber, Julien, Miranda, Melroy X., Liu, Yilei, van Tits, Lambertus J., Mateos, José María, Brokopp, Chad E., Auwerx, Johan, Thorens, Bernard, Lüscher, Thomas F., Matter, Christian M.
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2013
Sujets:
Original Contribution
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898152/
https://ncbi.nlm.nih.gov/pubmed/24370889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-013-0399-0
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