Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

Sirt3 is a mitochondrial NAD(+)-dependent deacetylase that governs mitochondrial metabolism and reactive oxygen species homeostasis. Sirt3 deficiency has been reported to accelerate the development of the metabolic syndrome. However, the role of Sirt3 in atherosclerosis remains enigmatic. We aimed t...

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書誌詳細
主要な著者: Winnik, Stephan, Gaul, Daniel S., Preitner, Frédéric, Lohmann, Christine, Weber, Julien, Miranda, Melroy X., Liu, Yilei, van Tits, Lambertus J., Mateos, José María, Brokopp, Chad E., Auwerx, Johan, Thorens, Bernard, Lüscher, Thomas F., Matter, Christian M.
フォーマット: Artigo
言語:Inglês
出版事項: Springer Berlin Heidelberg 2013
主題:
Original Contribution
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898152/
https://ncbi.nlm.nih.gov/pubmed/24370889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-013-0399-0
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