Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia

OBJECTIVE: Growing evidence suggests that a phenotypic switch converting pancreatic acinar cells to duct-like cells can lead to pancreatic intraepithelial neoplasia (PanIN) and eventually to invasive pancreatic ductal adenocarcinoma. Histologically, the onset of this switch is characterised by the c...

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Hauptverfasser: Prévot, Pierre-Paul, Simion, Alexandru, Grimont, Adrien, Colletti, Marta, Khalaileh, Abed, Van den Steen, Géraldine, Sempoux, Christine, Xu, Xiaobo, Roelants, Véronique, Hald, Jacob, Bertrand, Luc, Heimberg, Harry, Konieczny, Stephen F., Dor, Yuval, Lemaigre, Frédéric P., Jacquemin, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898034/
https://ncbi.nlm.nih.gov/pubmed/22271799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-300266
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