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Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling
Proteolytic processing of the amyloid precursor protein (APP) by the β- and γ-secretases releases the amyloid-β peptide (Aβ), which deposits in senile plaques and contributes to the etiology of Alzheimer's disease (AD). The α-secretase cleaves APP in the Aβ peptide sequence to generate soluble...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3897773/ https://ncbi.nlm.nih.gov/pubmed/24466315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087014 |
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