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Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.

So324 is a 2',3'-dideoxy-2',3'-didehydrothymidine-5'-monophosphate (d4T-MP) prodrug containing at the phosphate moiety a phenyl group and the methylester of alanine linked to the phosphate through a phosphoramidate linkage. So324 has anti-HIV activity in human CEM, MT4, and monocyte/macrophage cells...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Balzarini, J, Karlsson, A, Aquaro, S, Perno, C F, Cahard, D, Naesens, L, De Clercq, E, McGuigan, C
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38977/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692986/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.7295
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