Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-γ and Down-Regulation of VEGFR-2 Expression

15-lipoxygenase-1 (15-LOX-1) plays an important role in angiogenesis, but how it works still remains a controversial subject. The aims of our study are focused on determining whether or not 15-LOX-1 inhibiting oxygen-induced ischemic retinal neovascularization (RNV) and the underlying regulatory mec...

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Main Authors: Li, Zhi, He, Tao, Du, Ke, Xing, Yi-Qiao, Run, Yuan-Min, Yan, Ying, Shen, Yin
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897531/
https://ncbi.nlm.nih.gov/pubmed/24465728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085824
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