Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression

PURPOSE: 15-Lipoxygenase-1 (15-LOX-1) plays an important role in regulating angiogenesis, but the mechanism to date is controversial, even contradictory. The goal of our study was to investigate whether 15-LOX-1 plays a role in inhibiting retinal neovascularization (RNV) in a mouse model of oxygen-i...

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Main Authors: Li, Zhi, He, Tao, Du, Ke, Xing, Yi-Qiao, Yan, Ying, Chen, Zhen, Zhang, Hao, Shen, Yin
Formato: Artigo
Idioma:Inglês
Publicado: Molecular Vision 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519379/
https://ncbi.nlm.nih.gov/pubmed/23233787
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