LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-catenin/BCL9 Interaction

Abnormal activation of Wnt/β-catenin-mediated transcription is associated with a variety of human cancers. Here we report that LATS2 inhibited oncogenic Wnt/β-catenin-mediated transcription by disrupting the β-catenin/BCL9 interaction. LATS2 directly interacted with β-catenin and to be present on Wn...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Li, Jiong, Chen, Xiaohong, Ding, Xiangming, Cheng, Yingduan, Zhao, Bin, Lai, Zhi-chun, Hezaimi, Khalid Al, Hakem, Razqallah, Guan, Kun-liang, Wang, Cun-Yu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897473/
https://ncbi.nlm.nih.gov/pubmed/24360964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.037
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