LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-catenin/BCL9 Interaction

Abnormal activation of Wnt/β-catenin-mediated transcription is associated with a variety of human cancers. Here we report that LATS2 inhibited oncogenic Wnt/β-catenin-mediated transcription by disrupting the β-catenin/BCL9 interaction. LATS2 directly interacted with β-catenin and to be present on Wn...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Li, Jiong, Chen, Xiaohong, Ding, Xiangming, Cheng, Yingduan, Zhao, Bin, Lai, Zhi-chun, Hezaimi, Khalid Al, Hakem, Razqallah, Guan, Kun-liang, Wang, Cun-Yu
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897473/
https://ncbi.nlm.nih.gov/pubmed/24360964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.037
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk