Targeted Disruption of the BCL9/β-catenin Complex Inhibits Oncogenic Wnt Signaling

Deregulated Wnt/β-catenin signaling underlies the pathogenesis of a broad range of human cancers, yet the development of targeted therapies to disrupt the aberrant transcription has proven difficult because the pathway incorporates large protein interaction surfaces and regulates many homeostatic fu...

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Auteurs principaux: Takada, Kohichi, Zhu, Di, Bird, Gregory H., Sukhdeo, Kumar, Zhao, Jian-Jun, Mani, Mala, Lemieux, Madeleine, Carrasco, Daniel E., Ryan, Jeremy, Horst, David, Fulciniti, Mariateresa, Munshi, Nikhil C., Xu, Wenqing, Kung, Andrew L., Shivdasani, Ramesh A., Walensky, Loren D., Carrasco, Daniel Ruben
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631420/
https://ncbi.nlm.nih.gov/pubmed/22914623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003808
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