Targeted Disruption of the BCL9/β-catenin Complex Inhibits Oncogenic Wnt Signaling

Deregulated Wnt/β-catenin signaling underlies the pathogenesis of a broad range of human cancers, yet the development of targeted therapies to disrupt the aberrant transcription has proven difficult because the pathway incorporates large protein interaction surfaces and regulates many homeostatic fu...

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Detalhes bibliográficos
Main Authors: Takada, Kohichi, Zhu, Di, Bird, Gregory H., Sukhdeo, Kumar, Zhao, Jian-Jun, Mani, Mala, Lemieux, Madeleine, Carrasco, Daniel E., Ryan, Jeremy, Horst, David, Fulciniti, Mariateresa, Munshi, Nikhil C., Xu, Wenqing, Kung, Andrew L., Shivdasani, Ramesh A., Walensky, Loren D., Carrasco, Daniel Ruben
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631420/
https://ncbi.nlm.nih.gov/pubmed/22914623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003808
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