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Synthesis and Biophysical Characterization of Stabilized α-Helices of BCL-2 Domains

Rational design of compounds to mimic the functional domains of BCL-2 family proteins requires chemical reproduction of the biologic complexity afforded by the relatively large and folded surfaces of BCL-2 homology (BH) domain peptide α-helices. Because the intermolecular handshakes of BCL-2 protein...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Methods Enzymol
Main Authors: Bird, Gregory H., Bernal, Federico, Pitter, Kenneth, Walensky, Loren D.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384008/
https://ncbi.nlm.nih.gov/pubmed/18603134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0076-6879(08)01622-4
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