Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)

The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft anim...

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Main Authors: Xu, Xiang, Cai, Yuan, Wei, Ying, Donate, Fernando, Juarez, Jose, Parry, Graham, Chen, Liqing, Meehan, Edward J., Ahn, Richard W., Ugolkov, Andrey, Dubrovskyi, Oleksii, O'Halloran, Thomas V., Huang, Mingdong, Mazar, Andrew P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897428/
https://ncbi.nlm.nih.gov/pubmed/24465541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085349
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