An Improved Methodology for Multidimensional High-Throughput Preformulation Characterization of Protein Conformational Stability

The Empirical Phase Diagram (EPD) technique is a vector-based multidimensional analysis method for summarizing large data sets from a variety of biophysical techniques. It can be used to provide comprehensive preformulation characterization of a macromolecule’s higher-order structural integrity and...

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Hlavní autoři: Maddux, Nathaniel R., Rosen, Ilan T., Hu, Lei, Olsen, Christopher M., Volkin, David B., Middaugh, C. Russell
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897302/
https://ncbi.nlm.nih.gov/pubmed/22447621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23132
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