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Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity
The recent crystal structure of the κ-opioid receptor (κ-OR) revealed, unexpectedly, that the antagonist JDTic is a bivalent ligand: in addition to the orthosteric pocket occupied by morphinans, JDTic also occupies a distinct (allotopic) pocket. Mutagenesis data suggest that salvinorin A (1) also bi...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Beilstein-Institut
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896271/ https://ncbi.nlm.nih.gov/pubmed/24454571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.328 |
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