Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells

Homologous recombination deficient (HR(−)) mammalian cells spontaneously display reduced replication fork (RF) movement and mitotic extra centrosomes. We show here that these cells present a complex mitotic phenotype, including prolonged metaphase arrest, anaphase bridges, and multipolar segregation...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wilhelm, Therese, Magdalou, Indiana, Barascu, Aurélia, Técher, Hervé, Debatisse, Michelle, Lopez, Bernard S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2014
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896206/
https://ncbi.nlm.nih.gov/pubmed/24347643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311520111
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