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Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells
Homologous recombination deficient (HR(−)) mammalian cells spontaneously display reduced replication fork (RF) movement and mitotic extra centrosomes. We show here that these cells present a complex mitotic phenotype, including prolonged metaphase arrest, anaphase bridges, and multipolar segregation...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896206/ https://ncbi.nlm.nih.gov/pubmed/24347643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311520111 |
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