Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage

Upon DNA damage, tumor suppressor p53 determines cell fate by repairing DNA lesions to survive or by inducing apoptosis to eliminate damaged cells. The decision is based on its posttranslational modifications. Especially, p53 phosphorylation at Ser46 exerts apoptotic cell death. However, little is k...

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Bibliografske podrobnosti
Main Authors: Taira, Naoe, Yamaguchi, Tomoko, Kimura, Junko, Lu, Zheng-Guang, Fukuda, Shinji, Higashiyama, Shigeki, Ono, Masaya, Yoshida, Kiyotsugu
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896180/
https://ncbi.nlm.nih.gov/pubmed/24379358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313675111
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