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Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance
Drug resistance emerges in an ecological context where fitness costs restrict the diversity of escape pathways. These pathways are targets for drug discovery, and here we demonstrate that we can identify small-molecule inhibitors that differentially target resistant parasites. Combining wild-type an...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896170/ https://ncbi.nlm.nih.gov/pubmed/24381157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320886110 |
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