Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

Drug resistance emerges in an ecological context where fitness costs restrict the diversity of escape pathways. These pathways are targets for drug discovery, and here we demonstrate that we can identify small-molecule inhibitors that differentially target resistant parasites. Combining wild-type an...

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Detaylı Bibliyografya
Asıl Yazarlar: Lukens, Amanda K., Ross, Leila Saxby, Heidebrecht, Richard, Javier Gamo, Francisco, Lafuente-Monasterio, Maria J., Booker, Michael L., Hartl, Daniel L., Wiegand, Roger C., Wirth, Dyann F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896170/
https://ncbi.nlm.nih.gov/pubmed/24381157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320886110
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