Ableson Kinases Negatively Regulate Invadopodia Function and Invasion in Head and Neck Squamous Cell Carcinoma by Inhibiting an HB-EGF Autocrine Loop

Head and neck squamous cell carcinoma (HNSCC) has a proclivity for locoregional invasion. HNSCC mediates invasion in part through invadopodia-based proteolysis of the extracellular matrix (ECM). Activation of Src, Erk1/2, Abl and Arg downstream of epidermal growth factor receptor (EGFR) modulates in...

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Bibliographic Details
Main Authors: Hayes, Karen E., Walk, Elyse L., Ammer, Amanda Gatesman, Kelley, Laura C., Martin, Karen H., Weed, Scott A.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896120/
https://ncbi.nlm.nih.gov/pubmed/23146907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.513
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