The sex-specific associations of the aromatase gene with Alzheimer's disease and its interaction with IL10 in the Epistasis Project

Epistasis between interleukin-10 (IL10) and aromatase gene polymorphisms has previously been reported to modify the risk of Alzheimer's disease (AD). However, although the main effects of aromatase variants suggest a sex-specific effect in AD, there has been insufficient power to detect sex-spe...

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Hlavní autoři: Medway, Christopher, Combarros, Onofre, Cortina-Borja, Mario, Butler, Helen T, Ibrahim-Verbaas, Carla A, de Bruijn, Renée F A G, Koudstaal, Peter J, van Duijn, Cornelia M, Ikram, M Arfan, Mateo, Ignacio, Sánchez-Juan, Pascual, Lehmann, Michael G, Heun, Reinhard, Kölsch, Heike, Deloukas, Panos, Hammond, Naomi, Coto, Eliecer, Alvarez, Victoria, Kehoe, Patrick G, Barber, Rachel, Wilcock, Gordon K, Brown, Kristelle, Belbin, Olivia, Warden, Donald R, Smith, A David, Morgan, Kevin, Lehmann, Donald J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895636/
https://ncbi.nlm.nih.gov/pubmed/23736221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2013.116
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