The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

BACKGROUND: The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and...

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Main Authors: Combarros, Onofre, Warden, Donald R, Hammond, Naomi, Cortina-Borja, Mario, Belbin, Olivia, Lehmann, Michael G, Wilcock, Gordon K, Brown, Kristelle, Kehoe, Patrick G, Barber, Rachel, Coto, Eliecer, Alvarez, Victoria, Deloukas, Panos, Gwilliam, Rhian, Heun, Reinhard, Kölsch, Heike, Mateo, Ignacio, Oulhaj, Abderrahim, Arias-Vásquez, Alejandro, Schuur, Maaike, Aulchenko, Yurii S, Ikram, M Arfan, Breteler, Monique M, van Duijn, Cornelia M, Morgan, Kevin, Smith, A David, Lehmann, Donald J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994840/
https://ncbi.nlm.nih.gov/pubmed/21070631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-11-162
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