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A new regulatory pathway of mRNA export by an F-box protein, Mdm30
Mdm30, an F-box protein in yeast, has been recently shown to promote mRNA export. However, it remains unknown how Mdm30 facilitates mRNA export. Here, we show that Mdm30 targets the Sub2 component of the TREX (Transcription/Export) complex for ubiquitylation and subsequent proteasomal degradation. S...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3895266/ https://ncbi.nlm.nih.gov/pubmed/24327750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.042325.113 |
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