Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function

Neuronal Per-Arnt-Sim homology (PAS) Factor 4 (NPAS4) is a neuronal activity-dependent transcription factor which heterodimerises with ARNT2 to regulate genes involved in inhibitory synapse formation. NPAS4 functions to maintain excitatory/inhibitory balance in neurons, while mouse models have shown...

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Bibliographic Details
Main Authors: Bersten, David C., Bruning, John B., Peet, Daniel J., Whitelaw, Murray L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894988/
https://ncbi.nlm.nih.gov/pubmed/24465693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085768
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