Design and Synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (Citalopram) Analogues as Novel Probes for the Serotonin Transporter S1 and S2 Binding Sites

The serotonin transporter (SERT) is the primary target for antidepressant drugs. The existence of a high affinity primary orthosteric binding site (S1) and a low affinity secondary site (S2) has been described and their relation to antidepressant pharmacology has been debated. Herein, structural mod...

Full description

Saved in:
Bibliographic Details
Main Authors: Banala, Ashwini K., Zhang, Peng, Plenge, Per, Cyriac, George, Kopajtic, Theresa, Katz, Jonathan L., Loland, Claus Juul, Newman, Amy Hauck
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894853/
https://ncbi.nlm.nih.gov/pubmed/24237160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4014136
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items