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Structure-Activity Relationships for a Novel Series of Citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) Analogues at Monoamine Transporters

(±)-Citalopram (1, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile), and its eutomer, escitalopram (S(+)-1) are selective serotonin reuptake inhibitors (SSRIs) that are used clinically to treat anxiety and depression. To further explore structure-activity relat...

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Detalhes bibliográficos
Main Authors: Zhang, Peng, Cyriac, George, Kopajtic, Theresa, Zhao, Yongfang, Javitch, Jonathan A., Katz, Jonathan L., Newman, Amy Hauck
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932959/
https://ncbi.nlm.nih.gov/pubmed/20672825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1005034
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