Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

Neutrophil lifespan and function are regulated by hypoxia via components of the hypoxia inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for HIF-1α and prolyl hydroxylase-3. HIF-2α has both distinct and overlapping biological roles with HIF-1α and has not previo...

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Autors principals: Thompson, A. A. Roger, Elks, Philip M., Marriott, Helen M., Eamsamarng, Suttida, Higgins, Kathryn R., Lewis, Amy, Williams, Lynne, Parmar, Selina, Shaw, Gary, McGrath, Emmet E., Formenti, Federico, Van Eeden, Fredericus J., Kinnula, Vuokko L., Pugh, Christopher W., Sabroe, Ian, Dockrell, David H., Chilvers, Edwin R., Robbins, Peter A., Percy, Melanie J., Simon, M. Celeste, Johnson, Randall S., Renshaw, Stephen A., Whyte, Moira K. B., Walmsley, Sarah R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2014
Matèries:
Phagocytes, Granulocytes, and Myelopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894493/
https://ncbi.nlm.nih.gov/pubmed/24196071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-500207
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