Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

Neutrophil lifespan and function are regulated by hypoxia via components of the hypoxia inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for HIF-1α and prolyl hydroxylase-3. HIF-2α has both distinct and overlapping biological roles with HIF-1α and has not previo...

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Detalhes bibliográficos
Main Authors: Thompson, A. A. Roger, Elks, Philip M., Marriott, Helen M., Eamsamarng, Suttida, Higgins, Kathryn R., Lewis, Amy, Williams, Lynne, Parmar, Selina, Shaw, Gary, McGrath, Emmet E., Formenti, Federico, Van Eeden, Fredericus J., Kinnula, Vuokko L., Pugh, Christopher W., Sabroe, Ian, Dockrell, David H., Chilvers, Edwin R., Robbins, Peter A., Percy, Melanie J., Simon, M. Celeste, Johnson, Randall S., Renshaw, Stephen A., Whyte, Moira K. B., Walmsley, Sarah R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894493/
https://ncbi.nlm.nih.gov/pubmed/24196071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-500207
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