The Two Na(+) Sites in the Human Serotonin Transporter Play Distinct Roles in the Ion Coupling and Electrogenicity of Transport

Neurotransmitter transporters of the SLC6 family of proteins, including the human serotonin transporter (hSERT), utilize Na(+), Cl(−), and K(+) gradients to induce conformational changes necessary for substrate translocation. Dysregulation of ion movement through monoamine transporters has been show...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Felts, Bruce, Pramod, Akula Bala, Sandtner, Walter, Burbach, Nathan, Bulling, Simon, Sitte, Harald H., Henry, L. Keith
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2014
Aiheet:
Membrane Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894358/
https://ncbi.nlm.nih.gov/pubmed/24293367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.504654
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