The Two Na(+) Sites in the Human Serotonin Transporter Play Distinct Roles in the Ion Coupling and Electrogenicity of Transport

Neurotransmitter transporters of the SLC6 family of proteins, including the human serotonin transporter (hSERT), utilize Na(+), Cl(−), and K(+) gradients to induce conformational changes necessary for substrate translocation. Dysregulation of ion movement through monoamine transporters has been show...

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Bibliographic Details
Main Authors: Felts, Bruce, Pramod, Akula Bala, Sandtner, Walter, Burbach, Nathan, Bulling, Simon, Sitte, Harald H., Henry, L. Keith
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894358/
https://ncbi.nlm.nih.gov/pubmed/24293367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.504654
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