Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure

Nodal, a member of the TGF-β superfamily, plays an important role in vertebrate and invertebrate early development. The biochemical study of Nodal and its signaling pathway has been a challenge, mainly because of difficulties in producing the protein in sufficient quantities. We have developed a lib...

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Détails bibliographiques
Auteurs principaux: Esquivies, Luis, Blackler, Alissa, Peran, Macarena, Rodriguez-Esteban, Concepcion, Izpisua Belmonte, Juan Carlos, Booker, Evan, Gray, Peter C., Ahn, Chihoon, Kwiatkowski, Witek, Choe, Senyon
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894355/
https://ncbi.nlm.nih.gov/pubmed/24311780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.529180
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