HIV Protective KIR3DL1/S1-HLA-B Genotypes Influence NK Cell-Mediated Inhibition of HIV Replication in Autologous CD4 Targets

Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobulin-like Receptor (KIR)3DL1 with its ligand, HLA-B*57 (*h/*y+B*57) is associated with slower time to AIDS and better HIV viral load control than being a Bw6 homozygote (Bw6hmz). Natural Killer (NK) cells from...

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Détails bibliographiques
Auteurs principaux: Song, Rujun, Lisovsky, Irene, Lebouché, Bertrand, Routy, Jean-Pierre, Bruneau, Julie, Bernard, Nicole F.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894215/
https://ncbi.nlm.nih.gov/pubmed/24453969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003867
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