Modeling the estrogen receptor to growth factor receptor signaling switch in human breast cancer cells

Breast cancer cells develop resistance to endocrine therapies by shifting between estrogen receptor (ER)-regulated and growth factor receptor (GFR)-regulated survival signaling pathways. To study this switch, we propose a mathematical model of crosstalk between these pathways. The model explains why...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen, Chun, Baumann, William T., Clarke, Robert, Tyson, John J.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893882/
https://ncbi.nlm.nih.gov/pubmed/23994522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.08.022
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items