L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum

L-dopa remains the mainstay treatment for Parkinson's disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID). Current evidence links LID to excessive striatal L-dopa-derived dopamine (DA) release, while the possibility of a direct involvement of L-d...

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Main Authors: Porras, Gregory, De Deurwaerdere, Philippe, Li, Qin, Marti, Matteo, Morgenstern, Rudolf, Sohr, Reinhard, Bezard, Erwan, Morari, Michele, Meissner, Wassilios G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893648/
https://ncbi.nlm.nih.gov/pubmed/24429495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03730
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