Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis

BACKGROUND: A pathological hallmark of most amyotrophic lateral sclerosis (ALS) cases are intracellular aggregates of the protein TDP-43. The pathophysiological relevance of TDP-43 is underlined by familial ALS cases caused by TDP-43 mutations. TDP-43 is involved in processing of both coding RNAs an...

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Bibliografiske detaljer
Main Authors: Freischmidt, Axel, Müller, Kathrin, Ludolph, Albert C, Weishaupt, Jochen H
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893596/
https://ncbi.nlm.nih.gov/pubmed/24252274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-42
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