Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation

BACKGROUND: S-nitrosoglutathione (GSNO) serves as a reservoir for nitric oxide (NO) and thus is a key homeostatic regulator of airway smooth muscle tone and inflammation. Decreased levels of GSNO in the lungs of asthmatics have been attributed to increased GSNO catabolism via GSNO reductase (GSNOR)...

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Detalhes bibliográficos
Main Authors: Blonder, Joan P, Mutka, Sarah C, Sun, Xicheng, Qiu, Jian, Green, Lucia H, Mehra, Navdeep K, Boyanapalli, Ramakrishna, Suniga, Michael, Look, Kirsten, Delany, Chris, Richards, Jane P, Looker, Doug, Scoggin, Charles, Rosenthal, Gary J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893392/
https://ncbi.nlm.nih.gov/pubmed/24405692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2466-14-3
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