Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation

BACKGROUND: S-nitrosoglutathione (GSNO) serves as a reservoir for nitric oxide (NO) and thus is a key homeostatic regulator of airway smooth muscle tone and inflammation. Decreased levels of GSNO in the lungs of asthmatics have been attributed to increased GSNO catabolism via GSNO reductase (GSNOR)...

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Hlavní autoři: Blonder, Joan P, Mutka, Sarah C, Sun, Xicheng, Qiu, Jian, Green, Lucia H, Mehra, Navdeep K, Boyanapalli, Ramakrishna, Suniga, Michael, Look, Kirsten, Delany, Chris, Richards, Jane P, Looker, Doug, Scoggin, Charles, Rosenthal, Gary J
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893392/
https://ncbi.nlm.nih.gov/pubmed/24405692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2466-14-3
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