Pivotal Role of P450-P450 Interactions in CYP3A4 Allostery: the Case of α-Naphthoflavone

We investigated the relationship between oligomerization of cytochrome P450 3A4 (CYP3A4) and its response to α-naphthoflavone (ANF), a prototypical heterotropic activator. Addition of ANF resulted in over a two-fold increase in the rate of CYP3A4-dependent debenzylation of 7-benzyloxy-4-(trifluorome...

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Autori principali: Davydov, Dmitri R., Davydova, Nadezhda Y., Sineva, Elena V., Kufareva, Irina, Halpert, James R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893034/
https://ncbi.nlm.nih.gov/pubmed/23651100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130398
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