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Insulin Receptors in the Liver: Specific Binding of [(125)I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity

With [(125)I]insulin at 7 × 10(-10) M, 25% of the radioactivity was bound to plasma membranes purified from rat liver. 20% of the [(125)I]insulin binding was inhibited by unlabeled insulin at 10(-9) M (6 ng/ml), equivalent to insulin concentrations in hepatic portal blood; inhibition of [(125)I]insu...

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Detalhes bibliográficos
Main Authors: Freychet, Pierre, Roth, Jesse, Neville, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 1971
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC389303/
https://ncbi.nlm.nih.gov/pubmed/4331561
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