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Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations
Light chain amyloidosis is a devastating disease where immunoglobulin light chains form amyloid fibrils, resulting in organ dysfunction and death. Previous studies have shown a direct correlation between the protein thermodynamic stability and the propensity for amyloid formation for some proteins i...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3892967/ https://ncbi.nlm.nih.gov/pubmed/24157440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.10.016 |
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