CD38 Ligation in Peripheral Blood Mononuclear Cells of Myeloma Patients Induces Release of Protumorigenic IL-6 and Impaired Secretion of IFNγ Cytokines and Proliferation

CD38, a surface receptor that controls signals in immunocompetent cells, is densely expressed by cells of multiple myeloma (MM). The immune system of MM patients appears as functionally impaired, with qualitative and quantitative defects in T cell immune responses. This work answers the issue whethe...

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Главные авторы: Fedele, Giorgio, Di Girolamo, Marco, Recine, Umberto, Palazzo, Raffaella, Urbani, Francesca, Horenstein, Alberto L., Malavasi, Fabio, Ausiello, Clara Maria
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2013
Предметы:
Clinical Study
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892939/
https://ncbi.nlm.nih.gov/pubmed/24489445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/564687
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