CD38 Ligation in Peripheral Blood Mononuclear Cells of Myeloma Patients Induces Release of Protumorigenic IL-6 and Impaired Secretion of IFNγ Cytokines and Proliferation

CD38, a surface receptor that controls signals in immunocompetent cells, is densely expressed by cells of multiple myeloma (MM). The immune system of MM patients appears as functionally impaired, with qualitative and quantitative defects in T cell immune responses. This work answers the issue whethe...

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Detalhes bibliográficos
Main Authors: Fedele, Giorgio, Di Girolamo, Marco, Recine, Umberto, Palazzo, Raffaella, Urbani, Francesca, Horenstein, Alberto L., Malavasi, Fabio, Ausiello, Clara Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892939/
https://ncbi.nlm.nih.gov/pubmed/24489445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/564687
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