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Why tyrosine kinase inhibitor resistance is common in advanced gastrointestinal stromal tumors

Background: Most patients with advanced gastrointestinal stromal tumors (GIST) develop drug resistance to tyrosine kinase inhibitors (TKIs) within two years of starting therapy, whereas most chronic myeloid leukemia (CML) patients in chronic phase still exhibit disease control after a decade on ther...

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Bibliografiske detaljer
Main Authors: Tomasetti, Cristian, Demetri, George D, Parmigiani, Giovanni
Format: Artigo
Sprog:Inglês
Udgivet: F1000Research 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892920/
https://ncbi.nlm.nih.gov/pubmed/24555070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.2-152.v1
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