LRP1 protects the vasculature by regulating levels of Connective Tissue Growth Factor and HtrA1

OBJECTIVE: LRP1 is a large endocytic and signaling receptor that is abundant in vascular smooth muscle cells (SMC). Mice in which the lrp1 gene is deleted in SMC (smLRP1-/-) on an LDLr-deficient background display excessive PDGF signaling, SMC proliferation, aneurysm formation, and increased suscept...

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Detalhes bibliográficos
Main Authors: Muratoglu, Selen C., Belgrave, Shani, Hampton, Brian, Migliorini, Mary, Coksaygan, Turhan, Chen, Ling, Mikhailenko, Irina, Strickland, Dudley K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892666/
https://ncbi.nlm.nih.gov/pubmed/23868935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.301893
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